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Updated: Sep 13, 2025

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
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血管光滑肌细胞中的PP2Acα缺乏,通过调节KLF4酸化和化,加速大动脉动脉瘤和剖析

Wei-Peng Hu1,2,3,4,5, Ze-Yu Cai2,6, Qing-Le Li7

  • 1Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|July 28, 2025
PubMed
概括

蛋白酸酶2A催化子单元α (PP2Acα) 的缺乏会使大动脉动脉瘤和剖析 (AAD) 恶化. PP2Acα损失会损害血管光滑肌肉细胞收缩性,并通过稳定KLF4.4促进疾病进展.

关键词:
大动脉动脉瘤/切割克鲁佩尔之类的因素4现象型切换的切换蛋白酸酶2A是一种蛋白酸酶.血管光滑肌肉细胞细胞

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