泄漏性肠道与神经肌肉结节退化的接口;对严重的肉类的含义
Rizwan Qaisar1, Asima Karim2, Tahir Muhammad3
1Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Space Medicine Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Cardiovascular Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
概括
泄漏性肠道与严重的肉症中神经肌肉结节的退化有关. 这项研究发现,在老年人中,增加的肠道透性标记与肌肉损失和减少的身体功能相关.
科学领域:
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
- 胃肠病学 胃肠病学
背景情况:
- 肠道透性,或漏肠,与萨尔科佩尼亚 (与年龄相关的肌肉损失) 有关.
- 肠漏性肠道对神经肌肉结 (NMJs) 在肉症中的肌肉毒性影响尚不清楚.
- 这项研究调查了漏肠和NMJ降解在严重的肉症之间的联系.
研究的目的:
- 为了检查漏肠标记物和NMJ降解在严重的萨尔科佩尼亚的老年人之间的关联.
- 评估肠道透性,NMJ完整性和身体功能之间的关系.
- 探索细菌负载在这些关联中的作用.
主要方法:
- 测量了血中佐努林 (漏肠),CAF22 (NMJ降解) 和LBP (细菌负荷) 的水平.
- 手握强度,步行速度和SPPB被评估为肉症和功能妥协的标志物.
- 研究了一组对照组 (n=161) 和严重的肉男性 (n=148).
主要成果:
- 与对照人群相比,严重的sarcopenic患者表现出较高的zonulin,CAF22和LBP水平,以及较低的身体功能得分.
- 在zonulin和CAF22之间发现了显著的相关性,特别是在那些患有严重的肉症和低SPPB分数的人群中.
- 增加的佐努林和CAF22与增加的细菌负载以及肌肉力量和步行速度的降低相关.
结论:
- 严重的sarcopenia和功能衰退可能涉及NMJ降解和与肠道泄漏相关的细菌负载增加.
- 这些发现表明,肠道透性有助于导致肉症的潜在途径.
- 需要进一步的研究来证实肠漏和老年人肉症之间的因果和机制联系.
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