肠道失调影响多发性硬化症的病理生理学:北印度的一项病例对照研究
Gurkeerat Kaur1, Pallawi Kumari2, Priti Devi3
1Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
Journal of neuroimmunology
|July 28, 2025
概括
北印度多发性硬化症患者表现出肠道微生物多样性的减少和有益细菌的枯竭. 这种肠道失调与肠道透率的增加相关,这表明与疾病病理生理学的联系.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群的改变与诸如多发性硬化症 (MS) 这样的免疫媒介疾病有关.
- 了解特定人群的肠道微生物群,如北印度MS患者,至关重要.
研究的目的:
- 描述北印度MS患者的肠道微生物组概况.
- 评估肠道健康,使用肠道透性 (松素) 和炎症 (calprotectin) 的生物标志物.
主要方法:
- 招募了84名复发性复发性MS患者和106名健康对照.
- 使用Illumina MiSeq对肠道微生物群进行了测序,并通过ELISA对血清松素和便calprotectin进行了定量.
- 收集的临床,人口,人体和饮食数据.
主要成果:
- 与对照组相比,MS患者的α多样性较低,β多样性明显.
- 在MS中观察到,共生细菌 (例如,Faecalibacterium prausnitzii) 的显著减少和长链脂肪酸 (LCFA) 途径的丰富.
- 在多发性硬化症患者中发现了高素水平 (表明肠道泄漏),但calprotectin水平没有增加.
结论:
- 北印度RRMS患者呈现微生物多样性降低和开始性衰竭.
- 在MS患者中丰富的LCFA通路可能会促进炎症,并有助于增加肠道透性.
- 肠道失调和漏肠可能与MS病理生理学有关.
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