对多发性硬化症干预措施的系统审查的透明度:坚持GRADE方法 - 超级研究
Adriane Carvalho de Meneses1, Giullia Carvalho Mangas Lopes2, Letícia Barbosa de Lima1
1Department of Medicine, Universidade Metropolitana de Santos, Santos, Brazil.
Neuroepidemiology
|July 28, 2025
概括
对于多发性硬化症 (MS) 的系统审查很少使用推,评估,开发和评估 (GRADE) 的分级方法. 改善证据确定性评估对于可靠的MS护理建议至关重要.
科学领域:
- 医学研究 医学研究
- 证据综合 证据综合
- 系统审查是系统的审查.
背景情况:
- 多发性硬化症 (MS) 干预措施的系统审查的方法质量令人担忧.
- 评估证据的确定性对于可靠的决策至关重要.
- 推,评估,开发和评估 (GRADE) 的评级方法是证据确定性的标准.
研究的目的:
- 在对多发性硬化症干预措施的系统审查中评估GRADE方法的应用.
- 为了确定其使用范围和发现摘要 (SoF) 表的存在.
主要方法:
- 在主要数据库 (MEDLINE,Cochrane,Epistemonikos) 进行了全面的文献搜索.
- 对多发性硬化症干预措施的276个系统审查被评估了它们使用GRADE方法和结论摘要 (SoF) 表的情况.
主要成果:
- 在过去的十年中,观察到MS系统审查的趋势越来越大.
- 只有15%的审查系统审查使用了GRADE方法.
- 在使用GRADE的研究中,有83%的研究结果包含了结果总结表 (SoF),其中一半是Cochrane审查,其中SoF表是强制性的.
结论:
- 多发性硬化症系统性审查的方法严谨性存在重大差距.
- 需要加强对最佳实践的遵守,包括通过GRADE方法进行系统的确定性评估.
- 这将提高建议的可靠性,并支持在MS护理中基于证据的决策.
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