分享的运动和感知激活对神经假体解码的感觉运动皮质的影响
Alexander B Silva1,2,3, Jessie R Liu1,2, Vanessa R Anderson1
1Department of Neurological Surgery, University of California, San Francisco, CA, United States of America.
Journal of neural engineering
|July 28, 2025
概括
这项研究开发了一种使用电皮质谱 (ECoG) 的语音神经假体,即使在阅读和听力过程中也能准确地解码预期的语音. 该系统保持了对意志性语音尝试的特异性,这对于日常使用至关重要.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复技术 康复技术 康复技术
背景情况:
- 神经假肢的目的是通过解码来自感觉运动皮层 (SMC) 的语音运动运动来恢复患者的沟通.
- SMC参与了运动控制和感知处理 (视觉,听觉),引发了关于对语音解码的潜在干扰的问题.
- 了解共享的神经激活对于开发可靠的语音神经假体,用于阅读和倾听等日常活动至关重要.
研究的目的:
- 为患有声道的个体开发和评估基于电皮质谱 (ECoG) 的在线语音解码系统.
- 在日常任务中评估系统的准确性和特异性,包括阅读和听力.
- 研究SMC中试图发言,阅读和倾听反应的神经特征和空间分布.
主要方法:
- 开发了一个基于ECoG的在线语音解码系统,用于两名患有无关节炎的参与者.
- 在63.2分钟的言语和感知任务中测试了系统的性能.
- 对光谱时间特征和神经反应的空间分布进行了离线分析.
主要成果:
- 语音解码系统展示了零假阳性激活,保持高准确性和特异性对意志性语音尝试.
- 分享的神经群体响应试图说话,听话和阅读被确定,主要是在中部前中心中.
- 这些共享的群体使用了具有可差异化的光谱时间反应的独特的神经表征,这表明在语音运动规划中发挥了作用.
结论:
- 开发的解码框架使言语神经假体能够在日常活动中保持对意志性言语的特异性.
- 这项研究有助于理解SMC中共享的感知和运动活动是如何由神经假肢系统管理的.
- 可靠的语音神经假体在日常任务中保持特异性,对于改善沟通障碍患者的生活质量至关重要.
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