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基于IHC的分子分类在肌肉侵袭性尿路细胞膀癌:对临床适用的IHC标记面板的预后和预测价值 - 一个系统的审查

Andrada-Claudia Tătar¹, Andrada Loghin², Adela Nechifor-Boilă²

¹Histology Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures 540142, Romania; Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures 540142, Romania; Pathology Department, Mures Clinical County Hospital, Targu Mures 540011, Romania.

Critical reviews in oncology/hematology

|July 28, 2025

概括

尿路膀癌 (UBC) 亚型的免疫组织化学 (IHC) 分类预测了患者的结果和治疗反应. 像GATA3和CK5/6这样的关键IHC标志物为常规临床使用提供了实用的方法.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子诊断学分子诊断

背景情况:

泌尿器膀癌 (UBC) 具有分子多样性,影响治疗反应和治疗结果.
目前的分子分类方法对于日常使用来说是昂贵和复杂的.
免疫组织化学 (IHC) 为UBC亚型分类提供了一种可访问,具有成本效益的替代方案.

研究的目的:

评估基于IHC的UBC分类对瘤结果的预测价值.
评估IHC定义的亚型与治疗反应之间的相关性.
确定必要的IHC标记物,用于UBC的常规临床应用.

主要方法:

按照PRISMA指南,对PubMed和Scopus (2025年1月) 的系统文献搜索.
纳入2020年后对肌肉侵入性UBC患者的观察性研究,按IHC分类.
使用PICOS框架对IHC亚型与瘤结局和治疗反应的相关性分析.

主要成果:

发光性UBC亚型通常显示出改善的无进展生存率 (PFS),疾病特异性生存率 (DSS) 和整体生存率 (OS).
基础亚型表现出更好的无复发生存率 (RFS) 和对新辅助化疗 (NAC) 的优异反应.
双阳性亚型与改善的操作系统相关,而双阴性亚型表现最差的结果.

结论:

基于IHC的分类是分层UBC患者的实用和有前途的工具.
这种方法有助于预测瘤结果和治疗反应.
一个标准化的关键IHC标志物 (GATA3,CK5/6,p16,EGFR,维门丁) 面板可以提高临床实践和研究中的一致性和可重复性.

关键词:

免疫组织化学免疫组织化学分子分类的分子分类.尿路细胞膀癌是什么意思

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