基于全球生物监测数据的对人类暴露和健康风险的评估
Yunfei Liao1, Jiemei Li2, Xinyuan Li1
1Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Environmental research
|July 28, 2025
概括
全球对的暴露,包括甲基,在2000-2024年间显著下降. 虽然风险较低,但儿童和孕妇暴露率较高,因此需要持续监测.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物监测 生物监测
背景情况:
- 烯是广泛使用的防腐剂,具有潜在的内分泌干扰特性.
- 人们对与暴露相关的人类健康风险存在担忧.
研究的目的:
- 计算对的全球估计每日摄入量 (EDI) 和分组EDI (EDIGs).
- 评估2000年至2024年全球甲暴露趋势.
- 为了确定与暴露相关的潜在健康风险.
主要方法:
- 分析了来自29个国家的203个出版物的尿液 (N=370,460) 和血液 (N=19,521) 数据.
- 对甲基,乙基,基和乙类 parabens 的全球和分组 EDI 的计算.
- 评估暴露趋势和危险系数的评估.
主要成果:
- 甲基,乙基,基和乙类 parabens 的全球EDI 已在尿液和血液中确定.
- 各国观察到EDIG的显著差异,儿童和孕妇的暴露率更高.
- 从2000年到2024年,人们注意到帕拉暴露的全球持续下降,甲基帕拉从12.48至4.97μg/kg bw/day下降.
结论:
- 这项研究提供了使用生物监测数据对全球暴露的首次全面评估.
- 尽管出现下降趋势,但不能忽视暴露于的潜在健康风险.
- 调查结果突出了持续风险评估和对暴露的监测的需要.
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