探索抗腹配方对肠道氧化应激的影响,基于网络药理学,分子对接和微生物组学
Yi Ding1, Xueyan Wang1, Yichao Feng1
1College of Agronomy and Agricultural Engineering, Liaocheng University, Liaocheng 252000, China.
Fitoterapia
|July 28, 2025
概括
这种传统的中国草药配方通过减少氧化应激和改善肠道菌群来对抗痢疾. 它针对PI3K-Akt等关键途径,为肠道损伤提供了一种新的治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物组的分析
- 网络药理学 网络药理学
背景情况:
- 抗腹配方,一种传统的中国药物,已经显示出对牲畜腹的治疗效果.
- 它的作用机制,特别是在氧化应激方面,需要进一步研究.
研究的目的:
- 阐明抗腹配方在治疗腹中的药理机制.
- 通过微生物组分析和网络药理学,澄清其对氧化应激和肠道菌群的影响.
主要方法:
- 非向的代谢学来识别活性抗氧化成分.
- 网络药理学用于预测和分析分子标.
- 微生物组分析,以评估对小鼠肠道菌群的影响.
主要成果:
- 该配方通过PI3K-Akt信号通路向Src,Stat3,Akt1,Egfr,Hsp90aa1和Esr1,从而减少氧化应激和肠道损伤.
- 在改善肠道菌群和减少腹指数和免疫指标之间观察到显著的相关性.
- 确定了具有抗氧化功能的活性成分.
结论:
- 抗腹配方有效地减轻氧化应激和肠道损伤.
- 它的治疗作用通过PI3K-Akt途径和肠道微生物组的调节进行介导.
- 这项研究为传统使用这种草药化合物治疗痢疾提供了科学依据.
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