情绪稳定剂对双相情绪障碍认知的影响:随机对照试验的系统综述和元分析
Chang Qi1, Yuwei Wu1, Yufei Fan1
1West China School of Public Health, Sichuan University, Chengdu, China.
Journal of affective disorders
|July 28, 2025
概括
情绪稳定剂可以改善情绪处理和反应时间在青少年双相情绪障碍 (BD). 在青少年或成年人中,注意力和工作记忆等认知功能没有显著影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍 (BD) 是一种情绪障碍,通常用情绪稳定剂治疗.
- 认知缺陷在BD中很常见,影响日常功能.
- 了解情绪稳定剂对认知的影响对于治疗优化至关重要.
研究的目的:
- 审查和综合现有的证据,对情绪稳定剂治疗在患有双相情感障碍的患者的认知效应.
- 评估情绪稳定剂对特定认知领域的影响,包括注意力,工作记忆和情绪处理.
主要方法:
- 在主要的科学数据库 (PubMed,科学网,Embase,Cochrane图书馆,PsycInfo) 进行了系统的文献搜索.
- 数据提取和质量评估分别遵循PRISMA和Cochrane手册的指导方针.
- 使用RevMan 5.4软件对9项涉及570名患者的随机对照试验 (RCT) 数据进行了元分析.
主要成果:
- 在青少年BD患者中,心情稳定剂治疗显著改善了情绪处理精度 (SMD -1.18) 和延长反应时间 (SMD -0.39).
- 没有观察到对青少年注意力或工作记忆的显著影响,也没有观察到对成人整体认知功能的显著影响.
- 治疗也没有显著影响青少年的注意力或成人认知功能.
结论:
- 情绪稳定剂可以增强情绪处理,并延长BD青少年的反应时间.
- 这些治疗似乎不会影响青少年或成年人的整体认知功能或特定认知领域.
- 需要进一步的研究来证实这些初步发现,并阐明 BD 中情绪稳定剂的精确认知影响.
相关概念视频
01:24Mania and Antimanic Drugs: Overview
321
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
321
01:30Bipolar Disorder
144
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
144
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
208
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
208
01:28Drug Therapy
100
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
100
01:26Psychosis: Goals of Pharmacotherapy
209
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
209
01:23Antidepressant Drugs: MAOIs and Other Agents
358
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
358