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Updated: Sep 13, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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展开的蛋白质反应会影响慢性淋巴细胞白血病的治疗结果和疾病进展

Umair Tahir Khan1, Kim Clarke2, Gina Eagle1

  • 1Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Scientific reports
|July 28, 2025
PubMed
概括

展开的蛋白质响应 (UPR) 途径影响慢性淋巴细胞白血病 (CLL) 治疗结果. 用PERK抑制剂向UPR提高了在耐性CLL细胞中的fludarabine有效性.

关键词:
细胞中的CLL细胞.药物耐药性和疾病进展PERK与耐药表型相关.蛋白质组学是指蛋白质组学.通过eIF2信号传输.

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