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Updated: Sep 13, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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在切断的2,8-非替代性腺素支架中进行区域和立体选择性核糖修饰,以开发高强度的A2A腺素受体对手

Gibae Kim1,2, Seung Woo Kim1, Hongseok Choi1

  • 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Journal of medicinal chemistry
|July 28, 2025
PubMed
概括

研究人员修改了核糖衍生物,以改善人类腺A2A受体 (hA2AAR) 向. 脱氧衍生物4d显示出高强度和有效性,表明作为口服免疫检查点抑制剂的潜力.

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