可吞的光电子囊能够与工程微生物进行双向通信,用于可控制的治疗干预
Xinyu Zhang1, Zhijie Feng1,2, Hongxiang Li1
1School of Life Sciences, Faculty of Medicine, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin University, Tianjin, China.
Nature microbiology
|July 28, 2025
概括
研究人员使用工程细菌,可摄入囊和智能手机开发了一个系统来监测和治疗肠道炎症. 这种双向通信使得控制的诊断和 in vivo 的治疗干预成为可能.
科学领域:
- 合成生物学 合成生物学
- 光电学是指光电子产品.
- 微生物组工程 微生物组工程
背景情况:
- 工程微生物为体内传感和治疗提供了潜力,但缺乏实时监测和控制.
- 目前用于体内微生物应用的方法在为诊断和治疗提供双向通信的能力方面受到限制.
研究的目的:
- 建立一个由用户控制的双向通信系统,集成工程微生物,光电子囊和智能手机用于体内应用.
- 为了证明系统在诊断肠道炎症和提供有针对性的治疗干预措施方面的能力.
主要方法:
- 经过光遗传工程的Escherichia coli Nissle 1917被开发用于检测氧化,这是炎症的标志物.
- 一个可吞的光电子囊被设计成将微生物生物发光转化为智能手机监控的无线电信号.
- 智能手机接口被用来向囊发送无线信号,激活微生物生产和分泌抗炎纳米体.
主要成果:
- 经过工程设计的大肠杆菌在猪模型中成功检测出与炎症相关的氧化,产生生物发光信号.
- 光电子囊有效地将生物发光信号转换为无线传输的电信号,由智能手机监控.
- 通过智能手机控制的囊激活导致抗炎纳米体的微生物分泌,缓解了猪的结肠炎.
结论:
- 这项研究介绍了一种新的,集成的系统,用于在体内与工程微生物进行双向通信.
- 开发的平台展示了实时数字健康监测和精确控制的治疗干预的潜力.
- 将合成生物学与光电子相结合,为肠道微生物群中的先进诊断和治疗策略开辟了新的途径.
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