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Updated: Sep 13, 2025

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对于CYP3A和PXR而言,双人化的老鼠是通过CYP3A4调解的药物相互作用分析的改进模型

Kaoru Kobayashi1, Genki Minegishi2, Kanako Kazuki3

  • 1Department of Biopharmaceutics, Graduate School of Clinical Pharmacy, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. kaoruk@my-pharm.ac.jp.

The AAPS journal
|July 28, 2025
PubMed
概括

研究人员开发了一种新型的双人化大鼠模型,用于细胞染色体P450 3A4 (CYP3A4) 和孕妇X受体 (PXR). 这个模型准确地预测了人类的药物相互作用,包括CYP3A4诱导和抑制 in vivo.

关键词:
在CYP3A.染色体是一种染色体.药物相互作用 药物相互作用基因编辑 基因编辑孕妇的X受体受体.

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