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通过抑制双组分兰西胺毒素的生物合成来对抗毒性肠道细菌

Ryan Moreira1, Bidisha Chakraborty2, Yi Yang1

  • 1Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Nature communications
|July 28, 2025
PubMed
概括

研究人员开发了针对肠球菌细胞解酶成熟酶CylA的新型抑制剂. 这些化合物有效地阻断毒素活性和基因表达,为与这种细菌毒素相关的疾病提供了潜在的治疗策略.

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