在精神分裂症神经发育模型中的婴儿老鼠超声波发声
Agnieszka Potasiewicz1, Zuzanna Mincikiewicz2, Piotr Popik2
1Department of Behavioral Neuroscience and Drug Development, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland. potasiew@if-pan.krakow.pl.
Scientific reports
|July 28, 2025
概括
在大鼠中产前接触甲基氧甲醇酸盐 (MAM) 会损害幼的超声波发声 (USV),影响它们的发育,复杂性和时间. 这些声音缺陷可能表明早期精神分裂症相关的沟通障碍.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 动物模型 动物模型
背景情况:
- 精神分裂症涉及早期大脑发育异常影响沟通.
- 动物模型,如产前甲基氧甲醇酸盐 (MAM) 暴露,对于研究精神分裂症相关缺陷至关重要.
- 动物幼的超声波发声 (USV) 作为社会沟通的临床前模型.
研究的目的:
- 研究产前MAM暴露对大鼠幼中USVs的发育,结构和母体强化的影响.
- 使用机器学习分析USV特征,时间组织,聚类和语法.
- 识别精神分裂症相关的沟通缺陷的潜在早期标志物.
主要方法:
- 怀孕的老鼠在妊娠第17天暴露在MAM或盐水中.
- 后代的USV记录在出生后的6,9和12天.
- 在产后第10天测试了母体USVs的强化.
- 迪普斯奎克的机器学习算法分析了USV特征,时间模式和语法.
主要成果:
- 与对照组不同的是,暴露于MAM的幼显示出稳定的USV排放率和12日产后的较少的USV,与对照组不同.
- 在暴露于MAM的幼中,母体USV的强化很弱或不存在.
- MAM幼的USV复杂性 (带宽,频率) 降低,持续时间更长,发声时间延迟,呼叫间隔时间长,呼叫安排中断.
- 语法分析显示了一个简化的过渡模式,以低调调用为主.
结论:
- 产前MAM暴露显著扰乱了小鼠幼的语音沟通发展.
- 观察到的USV复杂性,时间和结构的缺陷可能是精神分裂症中负面症状或认知功能障碍的早期指标.
- 这项研究强调了USV在临床前模型中的实用性,以了解精神分裂症相关的沟通障碍.
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