在美国,过度活跃的膀与红细胞分布宽度与白蛋白比率的关联
Kun Zhou1,2, Zehui Rao1,2, Ingyu Chen1
1Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330000, China.
Scientific reports
|July 28, 2025
概括
红细胞分布宽度与白蛋白比率 (RAR) 的增加与美国成年人患过度活性膀 (OAB) 的风险更高有关. 这种新的炎症标志物可能有助于预测OAB的发展.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床医学 临床医学
- 炎症标志物 炎症标志物
背景情况:
- 过度活跃的膀 (OAB) 在全球范围内造成了重大的经济和生活质量负担.
- 红细胞分布宽度与专蛋白 (RAR) 的比率是一个新兴的炎症标志物.
- 美国成年人中RAR和OAB患病率之间的关联尚未得到充分证实.
研究的目的:
- 调查RAR水平与OAB在美国成年人群中的患病率之间的关系.
- 探索RAR在OAB开发中的预测价值.
主要方法:
- 使用2005-2020年NHANES数据进行的国家代表性横截面研究.
- 包括20岁以上的成年人,具有完整的RDW和专蛋白数据.
- 进行了多变量逻辑回归,受限立方线 (RCS) 和ROC曲线分析.
主要成果:
- 在RAR和OAB风险之间发现了显著的正相关性,即使对混因素进行了调整.
- 在最高RAR四分位数中的个人与最低四分位数相比,OAB的风险增加了41%.
- RCS分析表明存在非线性关系,年龄被确定为改变因素.
结论:
- 较高的RAR水平与美国成年人患膀过活的风险增加有关.
- RAR可能作为预测OAB发展的潜在生物标志物.
- 需要进一步的研究来探索RAR在OAB管理中的临床实用性.
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