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在自身免疫和炎症性类风湿性疾病中的动态巨细胞表型

Maurizio Cutolo^1,2, Stefano Soldano³, Vanessa Smith^4,5,6

¹Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova, Genova, Italy. mcutolo@unige.it.

Nature reviews. Rheumatology

|July 28, 2025

概括

巨细胞是自身免疫性疾病中至关重要的塑性细胞,表现出超出M1/M2.2的多样化表型. 了解它们在类风湿性关节炎和狼等疾病中的可塑性,是开发向治疗的关键.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
细胞生物学细胞生物学

背景情况:

巨细胞在调节风湿性疾病中的炎症和纤维化中发挥着核心作用.
巨细胞的可塑性允许它们在响应微环境线索时采用各种表型.
传统的M1/M2分类是不够的,有证据支持在体内存在巨细胞表型的连续性.

研究的目的:

调查驱动巨细胞可塑性和功能在自身免疫和炎症性类风湿性疾病的机制.
了解巨细胞的可塑性如何有助于类风湿性关节炎,牛皮性关节炎,全身性硬化症,全身性红斑狼,多性肌痛和巨细胞动脉炎的病理生理学.
探索针对巨细胞可塑性的治疗干预的潜力.

主要方法:

使用复杂的转录基因分析,分析受影响组织中的巨细胞表型.
检查突组织,纤维化皮肤和肺部,脏和突组织中的巨细胞可塑性.
综述现有的关于风湿性疾病中巨细胞行为的文献.

主要成果:

在各种类风湿性疾病中,巨细胞的可塑性在受影响的器官中显著增强.
转录组分析揭示了疾病活检中的多种宏细胞表型集群.
巨细胞的可塑性被认为是当前用于这些疾病的治疗药物的标.

结论:

巨细胞的可塑性是自身免疫和炎症性类风湿性疾病进展的关键因素.
了解巨细胞表型的谱和它们的调节对于疾病管理至关重要.
向巨细胞的可塑性有望在风湿病学中提供新的治疗策略.

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