在怀孕期间建立脂质概况参考范围:系统性审查和元分析
Liyun Sun1, Bingrui Gao1, Mingyue Wang1
1Department of Endocrinology and Metabolism, The Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110000, Liaoning, P.R. China.
Reproductive biology and endocrinology : RB&E
|July 28, 2025
概括
这项研究建立了母体脂质水平的三个月特定参考间隔 (TSRI),包括总胆固醇和甘油三,这对于准确的妊娠健康评估至关重要. 这些新范围改善了怀孕期间脱脂症的诊断.
科学领域:
- 产科和妇科 产科和妇科
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 在怀孕期间,母亲的脂质谱会发生显著的生理变化.
- 现有的成人脂质参考范围可能不准确地反映妊娠的特定需求或风险.
- 建立三个月特定的参考间隔 (TSRI) 对孕妇的健康至关重要.
研究的目的:
- 在怀孕期间确定总胆固醇 (TC),甘油三 (TG),HDL-c和LDL-c的TSRI.
- 调查影响整个妊娠期间母亲脂质水平的因素.
主要方法:
- 根据PRISMA/MOOSE指南,对13项观察性研究 (54,517名女性) 进行了系统审查和元分析.
- 使用随机效应模型计算聚合平均值和95%置信区间.
- 使用频率主义方法确定TSRI,通过AHRQ尺度评估研究质量.
主要成果:
- 对于TC,TG,HDL-c和LDL-c的确立TSRI,跨越三个季度,适用于普通和中国人群.
- 根据地理区域,测试方法和研究发表年份确定了脂质水平的变化.
- 在欧洲/南美女性中观察到较高的TC和基于测定方法和研究日期的不同TG/HDL-c水平.
结论:
- 准确诊断妊娠性失脂症需要适当的TSRI.
- 孕产妇的脂质水平受到地区,试验方法和研究时代的影响.
- 使用当前数据的区域和方法特定的TSRI是必要的,以提高诊断准确度.
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