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Updated: Sep 13, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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开发一种基于生理学的多用途综合性药理动力学模型用于crizotinib:口服溶液和小粒之间的生物等价性评估中的示例应用在儿科受试者中

Kazuko Sagawa1, Vivek Purohit2, Vu Le3

  • 1Pharmaceutical Science, Drug Product Design, Pfizer Research and Development, Groton, Connecticut, 06340, U.S.A.. kazuko.sagawa@pfizer.com.

The AAPS journal
|July 29, 2025
PubMed
概括

一个新的生理学基础的药理动力学 (PBPK) 模型证实了crizotinib颗粒与成人和儿童 (1-6岁) 的口服溶液具有生物等价性. 这种PBPK模型准确地预测了crizotinib配方的药物吸收和代谢.

关键词:
生物等价性 生物等价性基于模型的药物开发信息.PBPKK PBPK 的意思是什么意思儿科 儿科 儿科虚拟生物等价性 虚拟生物等价性

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