系统性炎症反应综合征与肝硬化和肝脏脑病变患者的预后之间的相关性
Kaiyue Zhang1, Ziqun Qu1, Rongyu Tang1
1Department of infectious disease and liver disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
BMC gastroenterology
|July 29, 2025
概括
系统性炎症反应综合征 (SIRS) 是肝硬化和肝脏脑病变 (HE) 的住院患者死亡的重要独立风险因素. 早期发现和管理SIRS对于改善这一脆弱人群的生存率至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
- 内部医学 内部医学
背景情况:
- 系统性炎症反应综合征 (SIRS) 与肝硬化进展有关.
- 肝硬化和肝脑病变 (HE) 的患者中SIRS的临床意义尚不清楚.
研究的目的:
- 研究SIRS在患有肝硬化和HE的住院患者中的临床意义.
- 确定SIRS作为这一患者群的死亡风险因素.
主要方法:
- 来自161名诊断为肝硬化和HE的住院患者的临床数据的分析.
- 使用单变Cox分析来确定住院死亡的风险因素.
主要成果:
- 60名患者 (37.3%) 患有SIRS,40名患者 (24.8%) 在住院期间死亡.
- SIRS和高的末期肝病模型 (MELD) 评分 (>18) 被确定为死亡率的独立风险因素.
- 随着SIRS得分的提高,以及MELD>18的患者,无论感染状态如何,死亡率都显著增加.
结论:
- 在住院肝硬化患者中,SIRS 是一种普遍且独立的死亡风险因素.
- 及时识别和治疗SIRS对于提高患者生存结果至关重要.
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