饮食中提供维生素A和非维生素A类胡卜素与中年和老年人的认知功能有关
Gulisiya Hailili1, Liyan Huang1,2, Minyu Wu1
1School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Nutrition journal
|July 29, 2025
概括
饮食中非维生素A类胡卜素与美国老年人更好的认知功能有关. 亲维生素A类胡卜素没有显示出整体相关性,但随着更高的视网醇摄入量出现了好处.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 饮食中的胡卜素与认知健康有关,但具体的子组影响尚不清楚.
- 了解胡卜素子组对认知的差异影响对于有针对性的饮食建议至关重要.
研究的目的:
- 调查特定的食类胡卜素子组 (益维生素A和非益维生素A) 与50岁及以上美国成年人的认知功能之间的关联.
- 探索血清细胞因子在胡卜素和认知之间的关系中的潜在调解作用.
主要方法:
- 使用来自健康和退休研究 (2013-2020) 的数据进行前性队列研究.
- 通过食物频率问卷评估饮食摄入量;用复合得分测量认知功能.
- 使用线性混合效应模型和调解分析来分析关联和炎症生物标志物的作用.
主要成果:
- 不提供维生素A类胡卜素的摄入量与认知功能有显著的积极关联 (0.288分高于顶部和底部五分之一).
- 这种关联部分由血清可溶性瘤亡因子受体1 (sTNFR-1) 介导.
- 普罗维他命A类胡卜素摄入量与整体认知功能没有显著的关联,但在摄入较高的视网醇的人群中出现了积极的关联.
结论:
- 在美国老年人中,不同类胡卜素子组和认知功能之间存在异质的关联.
- 非补充维生素A类胡卜素,特别是氨酸-叶绿素和柳科,可能有助于认知健康.
- 需要进一步的研究来证实这些发现,并阐明潜在的机制,可能涉及炎症途径.
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