在牙科试验中对Cochrane的ROB和ROB2进行比较评估:一项元研究研究
João Viana1, Vanessa Machado2, Luís Proença2
1Egas Moniz School of Health and Science, Egas Moniz Center for Interdisciplinary Research, 2829-511, Almada, Portugal. jviana@egasmoniz.edu.pt.
Systematic reviews
|July 29, 2025
概括
科克兰 (Cochrane) 公司的创始人.
科学领域:
- 牙科研究 牙科研究
- 证据综合 证据综合
- 超级研究 (Meta-Research) 是一种研究方法.
背景情况:
- 评估偏差风险对于评估临床试验质量至关重要.
- 科克伦的偏差风险 (RoB) 工具及其更新版本RoB2被广泛使用.
- 了解它们在牙科应用中的差异对于一致的证据评估至关重要.
研究的目的:
- 为了比较Cochrane偏差风险 (RoB) 和RoB2工具的性能.
- 评估在牙科随机临床试验中评估偏差时RoB和RoB2之间的协议.
- 确定牙科研究中的两个工具之间的偏差评估中的差异.
主要方法:
- 一项分析了150个牙科体内随机临床试验的元研究研究.
- 在2020-2022年间发表的试验从主要数据库 (PubMed/Medline,Scopus,EMBASE) 中进行了选择.
- 记录了影响因子,期刊四分位数,CONSORT遵守率和研究模型的数据.
主要成果:
- 只有33.3%的研究显示RoB和RoB2.2的偏差风险较低.
- 在RoB2的风险评估中,RoB降低了最初被归类为低风险的大量研究的风险评估 (29.6%对一些担忧,37%对高风险).
- 在牙科研究中,RoB和RoB2之间的总体一致性被发现很低.
结论:
- 在牙科中,Cochrane的RoB和RoB2工具之间存在明显的偏差评估差异.
- 这些差异可能会影响牙科研究中的证据综合和临床决策.
- 需要对RoB2在牙科试验中的应用和影响进行进一步的研究.
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