与围植性炎相关的表观遗传因素:一篇综述
Qianhui Li1, Hongye Lu1, Mengyuan Zhang1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
Journal of Zhejiang University. Science. B
|July 29, 2025
概括
表观遗传学,包括DNA甲基化和microRNAs,影响周植入炎. 了解这些机制为预防和治疗这种常见的牙科植入物并发症提供了新的策略.
科学领域:
- 口腔生物学和再生医学
- 分子生物学和遗传学 分子生物学和遗传学
- 牙科植入物学 牙科植入物学
背景情况:
- 牙周植入物疾病涉及骨损失和牙科植入物周围软组织炎症.
- 表观遗传学,基因表达的改变没有改变DNA序列,影响免疫反应,炎症和骨质新陈代谢.
- 表观遗传因素在围植入炎病原体中的作用尚未完全理解.
研究的目的:
- 审查表观遗传机制,特别是DNA甲基化和microRNAs (miRNAs) 与围植性炎之间的关联.
- 探索表观遗传修饰的潜力,以了解周植入炎的发展.
- 评估DNA甲基化和miRNAs对围植入炎的诊断和治疗潜力.
主要方法:
- 在PubMed,科学网,Scopus和谷歌学者上进行了全面的文献搜索.
- 关键词包括"表观遗传学"",围植入炎"",DNA甲基化"和"微RNA".
- 审查的重点是研究表观遗传修饰和围植入炎之间的联系的研究.
主要成果:
- DNA甲基化和miRNAs代表了与植入周围环境相关的动态表观遗传机制.
- 控制炎症和骨质生成的基因的表观遗传修饰提供了对周植入炎的见解.
- 这些表观遗传因素可能会调解局部和环境因素对疾病发展的影响.
结论:
- 表观遗传机制,DNA甲基化和miRNAs,在围植入炎中发挥作用.
- 这些发现为围部植入炎病原体提供了新的视角.
- 基因甲基化和miRNAs对未来的预防,诊断和治疗策略充满希望,用于围植入炎和其他炎症性口腔疾病.
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