小肠细菌过度生长和肠衰竭儿童的失生症:一个描述性的队列研究
Johannes Hilberath1, Andreas Busch2, Ulrich Schoppmeier3
1Pediatric Gastroenterology and Hepatology, University Children's Hospital Tübingen, Tübingen, Germany.
JPEN. Journal of parenteral and enteral nutrition
|July 29, 2025
概括
小肠细菌过度生长 (SIBO) 和失生症在患有肠道衰竭的儿童中很普遍,与肝脏问题和感染有关. 内镜方法和元基因组测序有效地诊断这些患者的SIBO.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 肠道功能失效管理 肠道功能失效管理
背景情况:
- 小肠细菌过度生长 (SIBO) 在儿科肠道衰竭中提出了诊断挑战.
- 评估SIBO和肠道失生症对于管理这些复杂的病例至关重要.
研究的目的:
- 为了评估患有肠道衰竭的儿童的SIBO和失生症.
- 为了比较用于SIBO诊断的不同采样方法.
- 为了将SIBO与临床特征和微生物组变化相关联.
主要方法:
- 一项描述性,单中心的队列研究,涉及44名患有肠衰竭的儿童.
- 收集内吸附物,刷毛片,粘膜活检和口腔便,用于SIBO诊断 (≥10^3 CFU/ml).
- 用于微生物组分析的全基因组测序;统计测试包括ROC分析和千平方测试.
主要成果:
- 在66%的样本中检测到SIBO,而93%的内镜方法的结果与内镜方法一致.
- SIBO阳性病例与小肠膨胀,PPI使用,炎症,肝酶升高和感染史相关.
- 甲基因组测序揭示了失生症,SIBO病例显示微生物读数增加,多样性减少,Enterobacteriaceae丰富度更高.
结论:
- 在儿科肠道衰竭中,SIBO和失生症很常见,与肝损伤和感染有关.
- 粘膜活检和刷毛片是SIBO诊断中可行的替代品.
- 大基因组测序是可行的,高微生物读数表明SIBO.
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