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在各种热条件下创建血类类似物以模仿稳定状态非牛顿剪切稀释特征

Hang Yi¹, Alexander Wang², Christopher Wang²

¹Department of Mechanical and Materials Engineering, Wright State University, 3640 Colonel Glenn Hwy., Dayton, OH 45435, USA.

Bioengineering (Basel, Switzerland)

|July 29, 2025

概括

研究人员开发了两种新鲜的血液类似物,它们精确地模仿了血液的非牛顿式剪切稀释特性. 这些类似物对于精确的血液动力学研究和医学诊断至关重要,特别是在温度敏感的应用中.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
材料科学材料科学材料科学

背景情况:

血液类似物对于体外研究 (如粒子图像速度测量 (PIV)) 对于理解血液动力学至关重要.
准确的物理性质,特别是非牛顿式剪切稀释行为,对于诊断心血管和神经血管疾病以及手术规划至关重要.
现有的血液类似物往往缺乏复杂的生理模拟所需的精确的风湿学特征.

研究的目的:

创建和描述两种类型的血液类型,这些类型准确地复制了人类血液的稳定状态剪切稀释粘度.
为这些类型在生理温度范围 (295-312 K) 和剪切速率范围 (1-250 s-1) 中建立公式.
为了验证模拟器的性能用于粒子图像速度测量 (PIV) 和血液动力学建模.

主要方法:

制造了两种血液类型:I型 (去离子水,桑坦) 和II型 (去离子水,桑坦,光微球).
在室温 (293.15 K) 下测量了质性 (粘度) 的风湿性质,并与已建立的血液粘度模型进行了比较.
通过最小化根的平均平方偏差来得出公式,并分析了温度和香度之间的相关性.

主要成果:

这两种血液类型都成功模仿了血液的剪切稀释粘度,平均相对差异低于5%.
在两种类型中,体温和香草度之间发现了强烈的线性相关性 (R2 > 0.96).
类型I需要在295-312K时达到140-520ppm,类型II需要在295-315K时达到200-560ppm.

结论:

开发的血液类似物为使用PIV进行准确的血液动力学研究提供了可靠和多功能平台.
这些类似物弥合了理想化模型和现实世界的生理条件之间的差距,增强了诊断和治疗应用.
这些发现支持生物医学技术的进步,特别是在温度敏感的环境和复杂疾病建模中.

关键词:

血液的模拟类型是血液的模拟.非牛顿主义的非牛顿主义.剪切削减-稀释削减-稀释稳定状态的稳定状态温度的温度的温度的温度的温度.

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