在微观结肠炎中肠道微生物群的失生症:诊断和治疗影响
Sanja Dragasevic1,2, Andreja Nikolic1, Sanja Zgradic1
1Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia.
微观结肠炎 (MC) 与肠道微生物群的变化有关,包括减少多样性和特定的细菌转移. 这些发现可能会导致新的诊断生物标志物和个性化治疗MC.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 微观性结肠炎 (MC) 是一种异常性炎症性肠病,导致水性腹,内镜检测结果正常.
- 肠道微生物群的变化越来越多地与MC的病原发生有关.
- 测序技术允许对微生物组成进行详细检查.
研究的目的:
- 审查MC肠道微生物群的病例控制研究的证据.
- 为了确定与MC相关的微生物模式.
- 探索这些模式作为诊断生物标志物和治疗点的潜力.
主要方法:
- 九项病例控制研究的叙事综述.
- 使用测序技术分析微生物组成.
- 在MC患者和对照人群中比较微生物特征.
主要成果:
- 在MC中观察到阿尔法多样性的减少和显著的失生症.
- 丰富口腔相关的种群 (例如, *Veillonella dispar*) 和保护性微生物 (例如, *Akkermansia muciniphila*, *Bacteroides stercoris*) 的耗尽.
- 尽管方法有所不同,但在所有研究中都存在一致的微生物趋势.
结论:
- 肠道微生物群的改变是MC的特征.
- 微生物形状显示出作为非侵入性诊断生物标志物的潜力.
- 描述肠道微生物群可以指导个性化疗法,如益生菌或便微生物群移植.
- 需要进一步标准化,纵向研究.
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