在高血压患者中,代谢生物标志物和脉冲波分析之间的交叉连接
Mirela Baba1,2, Mihaela Ioana Maris2,3, Adina Bucur2,4
1Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Biomedicines
|July 29, 2025
概括
高血压与血管变化和脂质代谢有关. 这项研究发现,脂质样本和代谢生物标志物与脉冲波分析相关,有助于在高血压患者中早期检测血管损伤.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征研究 代谢综合征研究
- 血管生物学 血管生物学
背景情况:
- 高血压与血管功能和脂质代谢的改变有关.
- 了解这些联系对于管理心血管风险至关重要.
研究的目的:
- 研究高血压患者的脂质样本,代谢生物标志物和脉冲波分析之间的关系.
- 评估这些标记物在识别血管变化的有用性.
主要方法:
- 对66名高血压患者进行了脉冲波分析,使用了振荡计装置.
- 测量了血清脂质生物标志物 (总胆固醇,甘油三,非HDL胆固醇) 和脂质平衡指数 (LBI).
- 分析了与代谢综合征,胰岛素耐药性和非酒精性脂肪肝疾病 (NAFLD) 的相关性.
主要成果:
- 静脉血压 (SBP),静脉血压 (DBP) 和早期血管衰老 (EVA) 显示与脂质生物标志物的相关性.
- 代谢综合征,胰岛素耐药性和NAFLD与脉冲波分析变量有显著联系.
- 在回归分析中,总胆固醇 (TC) 仍然与DBP显著相关.
结论:
- 脂质概况 (TC,TG,非HDL,LBI) 提供了对高血压和高血压中EVA的见解.
- 在高血压患者中,LBI对于评估心血管风险因素,EVA,胰岛素抵抗和NAFLD的血管健康是有价值的.
- 整合代谢生物标志物和脉冲波测量提供了早期血管损伤检测和心血管事件预测的综合方法.
相关概念视频
01:17Measurement of Blood Pressure
1.5K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.5K
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
48
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
216
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
216
01:16Pulse
1.1K
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
The pulse serves as a clinical...
1.1K
01:30Pulse rhythm
929
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
929
01:28Special considerations while measuring blood pressure
824
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
824