在ILD的内型和表型:是时候重新分类ILD风险分层吗?
Francesco Amati1,2, Anna Stainer1,2, Stefano Aliberti1,2
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
Biomedicines
|July 29, 2025
概括
间歇性肺部疾病 (ILD) 是复杂的肺部疾病,具有多种炎症和纤维化. 早期诊断和量身定制的治疗对于改善这些具有挑战性的呼吸系统疾病患者的治疗结果至关重要.
科学领域:
- 肺病学和呼吸系统医学
- 病理学和医学研究.
背景情况:
- 间歇性肺部疾病 (ILD) 代表了一组多样化的肺部疾病.
- 这些疾病带来了诊断和治疗方面的挑战,原因是肺组织的不同程度的炎症和纤维化.
研究的目的:
- 阐明间歇性肺部疾病的复杂性.
- 突出在ILD诊断和管理方面的挑战.
- 为了强调在ILD中肺炎和纤维化的多样性.
主要方法:
- 审查关于ILD的现有文献.
- 对ILD的诊断标准的分析.
- 检查目前的ILD管理策略.
主要成果:
- ILD异质性使准确的诊断变得复杂.
- 纤维化和炎症模式在ILD亚型之间存在很大差异.
- 标准化的管理方法往往是不够的.
结论:
- 了解ILD异质性是关键的.
- 需要对ILD进行改进的诊断工具.
- 个性化治疗策略对于ILD管理至关重要.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
291
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
291
Pulmonary Tuberculosis III
446
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
446
Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
Heart Failure IV: Classification and Diagnostic Evaluation
33
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
33
Chronic Obstructive Pulmonary Disease-I: Introduction
2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
COPD: Pathogenesis and Clinical Features
528
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
528


