类药物对乳腺癌患者全因死亡率的影响:一项基于人口的研究
Ching-Feng Cheng1,2, Chao-Hsu Li2,3, Joshua Wang4
1Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Biomedicines
|July 29, 2025
概括
乳腺癌患者使用静止剂与五年内所有原因死亡率显著降低有关. 这种保护作用在老年患者和患有特定瘤类型或代谢状况的患者中更为明显.
科学领域:
- 在瘤学瘤学.
- 心血管研究研究心血管研究
- 药理学 药理学 是一个学科.
背景情况:
- 乳腺癌是全球主要的死亡原因之一.
- 类药物广泛用于预防心血管疾病.
- 对于他类药物对乳腺癌结局的影响需要进一步阐明.
研究的目的:
- 对乳腺癌患者的他类药物使用与5年临床结果之间的关联进行调查.
- 评估他类药物对该人口所有原因死亡率的影响.
- 确定可能从他类药物治疗中受益最多的患者子组.
主要方法:
- 使用TriNetX平台数据 (2010-2020) 的回顾性队列研究.
- 包括971,808名乳腺癌患者,分为他类药物使用者 (98,761) 和非使用者 (691,644).
- 1: 1 倾向性得分匹配,然后使用阿伦-约翰森曲线,危险比率和风险比率分析所有原因死亡率和心血管发病率.
主要成果:
- 与不使用者相比,使用他类药物的死亡风险明显较低 (危险比率:0.798;风险比率:0.721;p < 0.001).
- 亚组分析表明,在老年患者中,那些BMI较高,胆固醇/甘油三/LDL水平升高以及荷尔蒙受体阴性瘤的患者中,保护作用得到增强.
- 立方体使用与改善生存率有关,特别是在老年患者,荷尔蒙受体阴性瘤患者和代谢失调患者中.
结论:
- 立方体使用与乳腺癌患者全因死亡率的降低有关.
- 在特定的亚组中,他类药物的益处更为明显,包括老年患者和患有荷尔蒙受体阴性瘤或代谢失调的患者.
- 需要进一步的前性研究来证实这些发现并探索潜在的机制.
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