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异酸脱酶野生型质瘤适应变异性表型和增强治疗敏感性在D-2-氧酸盐暴露下

Geraldine Rocha1,2, Clara Francés-Gómez1,2, Javier Megías1,2

  • 1Department of Pathology, University of Valencia, 46010 Valencia, Spain.

Biomedicines
|July 29, 2025
PubMed
概括

在质母细胞瘤 (GBM) 中的异酸脱酶 (IDH) 突变最初会减缓生长,但会增加对temozolomide和辐射的敏感性. 代代谢物2-基酸盐 (2HG) 模仿了这些效应,表明了治疗的脆弱性.

关键词:
2 - 基氨酸二氧化.IDH IDH 是一个字母.作为辅助剂的放射治疗.星系细胞瘤是一个星系细胞瘤.在瘤中产生耐药性.质母细胞瘤 (glioblastoma) 是一种质瘤 质瘤 是一种异酸盐脱基酶突变异位基因异种植的模型 异种植的模型

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