从跳转基因到癌症:重新审视JTB蛋白质的作用
Taniya M Jayaweera1, Madhuri Jayathirtha1, Krishan Weraduwage1
1Biochemistry & Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY 13699, USA.
Biomedicines
|July 29, 2025
概括
跳跃转位 (JTs) 是一种罕见的染色体异常,与癌症进展有关. 跳跃转位断点 (JTB) 基因的基因.
科学领域:
- 遗传学和分子生物学
- 癌症生物学 癌症生物学
- 基因组不稳定性 基因组不稳定性
背景情况:
- 跳跃转位 (JTs) 是一种罕见的染色体异常,经常在各种癌症中观察到,通常与瘤进展和不良预后有关.
- 这些重排,特别是涉及1q染色体的重排,突显了基因组不稳定性在瘤发生过程中的重要性.
- 人类的跳转转位断点 (JTB) 基因在转位断点被识别出来,这表明它在这些关键的基因组事件中的作用.
研究的目的:
- 审查JTB基因在癌症发病过程中的多方面的作用.
- 探索JTB作为诊断生物标志物和治疗点的潜力.
- 强调需要在癌症中继续对JTB进行多项研究.
主要方法:
- 文献综述综合了基因组,转录组和蛋白质组研究的发现.
- 分析JTB在关键细胞过程中的功能性作用,如线粒分裂和亡.
- 检查JTB参与与癌症相关的途径,如上皮层-介质细胞过渡 (EMT) 和免疫逃避.
主要成果:
- JTB蛋白质是线粒分裂,染色体分离,细胞亡和细胞代谢的关键调节者.
- 联合结核病与染色体乘客复合体 (CPC) 有功能联系,并影响EMT和免疫逃避.
- 结核瘤表现出取决于情境的作用,在不同类型的癌症,特别是乳腺癌和前列腺癌中充当瘤抑制剂和瘤基因.
结论:
- 在癌症生物学中,JTB扮演着重要的,取决于背景的角色,影响瘤的进展和治疗耐药性.
- 作为诊断生物标志物和新型癌症治疗的潜在目标,JTB具有前景.
- 进一步对JTB进行多层次的研究 (基因组,转录组,蛋白质组) 对于推进癌症管理策略至关重要.
更多相关视频
07:23A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
Published on: September 11, 2013
9.6K
07:28JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
Published on: October 19, 2021
3.3K
相关概念视频
01:33Cancer-Critical Genes I: Proto-oncogenes
9.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.2K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.0K
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
01:12Loss of Tumor Suppressor Gene Functions
5.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.1K
02:38The Ras Gene
6.4K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.4K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K