肠道微生物甲基醇代谢会影响人类生理吗?
Oluwatomisono I Akinrimisi1, Kim Maasen2, Jean L J M Scheijen2,3
1Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Science Institute, Amsterdam University Medical Center, location AMC, 1105 AZ Amsterdam, The Netherlands.
Antioxidants (Basel, Switzerland)
|July 29, 2025
概括
肠道微生物通过改变宿主新陈代谢和直接微生物合成或排毒来影响体内的甲基甘 (MGO) 水平. 针对肠道微生物组提供了一种新的策略,以减少MGO压力和预防心脏代谢疾病.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 氧化压力是一种氧化压力.
背景情况:
- 甲基醇 (MGO) 是一种与氧化应激,炎症和慢性疾病 (如糖尿病血管并发症和动脉样硬化) 相关的活性二乙.
- MGO形成主要归因于宿主糖解,但肠道微生物群在心脏代谢疾病发展中的作用越来越被认可.
研究的目的:
- 探索肠道微生物调节宿主甲基酸盐 (MGO) 水平的能力.
- 研究饮食中MGO对肠道微生物群组成和宿主健康的影响.
- 突出针对肠道微生物群的潜力,以管理心脏代谢疾病中MGO相关的压力.
主要方法:
- 关于肠道微生物群和MGO新陈代谢之间的相互作用的文献综述和概念讨论.
- 对现有观察结果的分析,支持肠道微生物在MGO调节中的作用.
- 探索饮食中MGO对微生物群和宿主健康的影响.
主要成果:
- 肠道微生物可以通过改变宿主新陈代谢和直接MGO合成或排毒来影响宿主MGO池.
- 饮食MGO影响肠道微生物群的组成,可能影响宿主健康.
- 肠道微生物组在MGO稳态中的作用提出了一个创新的范式.
结论:
- 肠道微生物群在宿主MGO监管中是一个重要的,但被低估的因素.
- 针对肠道微生物群的干预措施 (例如,益生菌,益生菌,FMT) 为减少MGO压力提供了一个新的治疗策略.
- 调节肠道微生物组可能有助于减轻糖尿病并发症和心血管疾病负担.
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