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愤怒抑制剂TTP488 (Azeliragon) 改善了白素缺乏肥胖小鼠的糖尿病膀功能障碍

Akila Lara Oliveira1, Matheus Leite Medeiros1, Antonio Thiago Pereira Campos2

  • 1Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas 13084-971, SP, Brazil.

Antioxidants (Basel, Switzerland)
|July 29, 2025
PubMed
概括

使用TTP488的RAGE阻塞通过减少AGE和原蛋白,使酶活性正常化,并恢复膀功能,改善了小鼠糖尿病膀功能障碍. 这表明RAGE抑制是糖尿病膀问题的潜在治疗方法.

关键词:
原蛋白是一种原蛋白.葡萄糖氨酸氨酸是什么?氧-1酶-1的使用方法甲基格里奥克萨尔 (Methylglyoxal) 是一种甲基醇衍生型的胺醇.超氧化物脱酶的作用空点检测试验 (void spot assay) 是一种空点检测试验.

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