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蜂提取物具有对菌的活性,生物膜向病毒性基因表达

Sophia Athanasopoulou¹, Eleni Panagiotidou¹, Eleni Spanidi¹

¹Research and Development Department, APIVITA SA, Industrial Park Markopoulo Mesogaias, 19003 Athens, Greece.

Antioxidants (Basel, Switzerland)

|July 29, 2025

概括

这项研究表明, (PE) 提取物有效向导致的Cutibacterium acnes (C. acnes) 生物膜. 皮肤微生物提供了抗生素的潜在替代品,可以保护皮肤微生物群的多样性并减少炎症.

科学领域:

皮肤病学皮肤病学
微生物学微生物学
自然产品化学化学

背景情况:

是一种常见的皮肤疾病,是由Cutibacterium acnes (C. acnes) 的过度生长和炎症引起的.
对的抗生素治疗可以导致抗菌素耐药性,并破坏皮肤微生物群.
菌形成生物膜,有助于持续性感染和治疗挑战.

研究的目的:

为了评估标准化提取物 (PE) 对C. acnes.的疗效.
研究PE对C. acnes生物膜形成和毒性基因的影响.
评估PE维持皮肤微生物群生物多样性和调节炎症反应的能力.

主要方法:

使用GC-MS对PE的化学表征.
通过Folin-Ciocalteu和DPPH测定对抗氧化物质的评估.
评估PE对C. acnes生物膜的形成,基因表达 (毒性,抗微生物,抗炎) 和正常的人类表皮角质细胞 (NHEKs) 的影响.

主要成果:

标准化的 прополис提取物显示出对抗C. acnes的显著有效性.
发现PE降低了与C. acnes附着,殖民和生物膜形成相关的基因.
提取物表现出抗氧化特性,并调节了NHEKs中的抗微生物和抗炎基因表达,同时保持了微生物群的生物多样性.

结论:

标准化石提取物通过向C. acnes生物膜,为治疗提供了一个有希望的替代方案.
皮质前列腺抑制毒性因素并保持皮肤微生物群平衡的能力提供了一个新的治疗策略.
这项研究支持开发新一代,微生物群友好的治疗方法,这些治疗方法来源于天然产品.

关键词:

这种细菌是Cutibacterium acnes.生物膜是一种生物膜.的提取物的提取物

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