高铁醇/氧铁醇 超处女橄油 增强老年肌动脉梗塞后患者的抗氧化活性
Mojgan Morvaridzadeh1, Mehdi Alami1, Nada Zoubdane1
1Geriatrics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.
富含的特级初橄油 (HP-EVOO) 显著增加了抗氧化能力,通过FRAP和PON-1活性测量,在老年人心肌梗塞 (MI) 后的个人中. 这表明HP-EVOO可能会在这个人群中有益于心血管健康.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 氧化压力研究研究 氧化压力研究
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因,与氧化应激和脂质代谢障碍有关.
- 额外处女橄油 (EVOO) 含有具有潜在抗氧化和抗炎功效的化合物.
- 对于EVOO基对老年人,特别是心肌梗塞 (MI) 后患者的特定影响,需要进一步研究.
研究的目的:
- 研究EVOO化合物对氧化应激生物标志物和高密度脂蛋白 (HDL) 功能的影响.
- 为了比较高EVOO (HP-EVOO),标准EVOO和精炼橄油 (ROO) 在健康和MI后老年人的影响.
- 评估26周干预后相关的代谢结果.
主要方法:
- 一项试点随机临床试验,涉及健康和后心脏病发作的老年参与者 (65-85岁).
- 参与者每天摄入25毫升HP-EVOO,EVOO或ROO,持续26周.
- 在基线和干预后测量了包括血 (多) ,甲 (MDA),FRAP,LCAT和血清氧酶-1 (PON-1) 活性在内的关键生物标志物.
主要成果:
- 与基线相比,食用HP-EVOO的老年后MI参与者显示,总抗氧化能力 (FRAP) 和血清偏氧酶-1 (PON-1) 活性显著增加 (p=0.014).
- 两组之间没有观察到马隆迪甲基 (MDA) 水平,莱西丁胆固醇乙转移酶 (LCAT) 活性或血 (多) 水平的显著变化.
- 基线特征和炎症标志物在各组之间相似,这表明潜在的心脏代谢状态可能会影响反应.
结论:
- 摄入高含量的特级初橄油 (HP-EVOO) 可能会在经历过心肌梗塞的老年人中增强抗氧化能力.
- 这些发现表明,个人的心脏代谢状态可能会调节他们对橄油中化合物的反应.
- 需要进一步的研究来阐明HP-EVOO在特定老年人群中的长期心血管益处和机制.
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