维奥拉菲利皮卡多聚醇提取物的抗氧化和光保护作用
Jiang Li1,2, Jiancheng Ma1,3, Ya Li1
1State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Antioxidants (Basel, Switzerland)
|July 29, 2025
概括
维奥拉菲利普皮卡多提取物显示出对皮肤光保护的显著潜力. 特定的提取物显示出抗氧化和紫外线保护性质,为化品配方提供天然解决方案.
科学领域:
- 植物化学 植物化学
- 皮肤病学 皮肤病学
- 化品科学 化品科学
背景情况:
- 紫 (Viola philippica,简称VP) 是一种以抗菌和抗氧化特性而闻名的中国传统药用草本.
- 最近的兴趣主要集中在其对抗紫外线损伤的皮肤光保护潜力上.
- 甘油 (GLY),1,3-二醇 (PDO) 和1,3-butanediol (BDO) 被用作提取溶剂.
研究的目的:
- 评估使用不同聚醇溶剂和度获得的维奥拉菲利普卡提取物的抗氧化和紫外线保护性质.
- 为了确定特定的提取物,以皮肤光保护的最佳有效性.
- 阐明保护作用背后的分子机制.
主要方法:
- 提取Viola philippica使用GLY,PDO和BDO的30%,60%和90%度.
- 总含量 (TPC) 和总黄含量 (TFC) 的量化.
- 抗氧化剂测定 (DPPH,ABTS,OH激素) 和UVB诱导的细胞损伤测定 (ROS,DNA损伤).
- 用于分子路径分析的RNA测序 (RNA-seq).
主要成果:
- 在提取物中,TPC和TFC各不相同,最高的TPC在90%的PDO中,最高的TFC在60%的GLY中.
- 抗氧化剂活性在各个测试中显示出不同的IC50值.
- 60%的GLY,30%的PDO和90%的PDO提取物对UVB诱导的细胞损伤提供了显著的保护.
- RNA-seq确定了中性粒细胞外细胞陷形成和TNF,IL-17和HIF-1信号传递等途径的调制.
结论:
- 维奥拉菲利普卡多提取物具有有前途的抗氧化和光保护能力.
- 使用60%的GLY,30%的PDO和90%的PDO的提取物特别有效.
- 这些发现支持Viola philippica提取物作为用于皮肤光保护的化品配方中的天然成分的使用.
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