CT纹理模式反映了HPV状态,但不是口腔状细胞癌的组织学差异化
Lays Assolini Pinheiro de Oliveira1,2, Caio Elias Irajaya Lobo Peresi1, Daniel Vitor Aguiar Nozaki3
1Department of Anesthesiology, Oncology and Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil.
Cancers
|July 29, 2025
概括
对CT扫描的纹理分析可以根据HPV状态区分口腔瘤. 阳性HPV瘤在成像上显示出更高的复杂性和异质性,有助于诊断.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 纹理分析 (TA) 显示了表征内异质性的潜力.
- 以前的研究表明,TA可以根据HPV状况区分口腔癌.
研究的目的:
- 评估基于CT的纹理分析在根据HPV状况区分口腔状细胞癌 (OP SCC) 的能力.
- 为了研究纹理特征和组织学等级之间的相关性.
主要方法:
- 120名OP SCC患者的多切片CT分析.
- 使用灰色级别共发生矩阵提取纹理特征.
- 评估HPV阳性和HPV阴性瘤之间的纹理参数差异.
主要成果:
- 七个纹理参数在HPV阳性和HPV阴性瘤之间显著不同 (p <0.05).
- 阳性HPV瘤在CT成像上显示异质性和复杂性增加.
- 在纹理特征和组织学等级之间没有发现显著的相关性.
结论:
- 基于CT的TA在评估OP SCC中的HPV状况方面显示出希望.
- 在放射学工作流程中,TA可以作为诊断和治疗计划的辅助方法.
- 临床整合需要进一步验证.
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