利用液基因因:一种基于黄类的方法,用于预防和治疗癌症
Anjana Sajeev1, Babu Santha Aswani1, Mohammed S Alqahtani2,3
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India.
甘草中的天然化合物液化基因因 (LIQ) 是一种有希望的,作为一种不那么有毒的癌症治疗方法. 它通过诱导亡和调节关键信号通路来表现出抗癌作用,为化疗提供了潜在的替代方案.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 自然化合物越来越多地被认为是传统化疗的高效,低毒性和低成本替代品.
- 液化基因素 (LIQ) 是一种从植物中提取的生物活性化合物,特别是Glycyrrhiza物种 (甘草).
研究的目的:
- 审查关于LIQ药理效应的临床前发现,重点关注其抗癌潜力.
- 突出LIQ在各种癌症类型的治疗效果及其在向瘤生长中的作用.
主要方法:
- 临床前研究和实验研究文章的汇编.
- 在科学数据库中对LIQ的抗癌特性和相关信号通路的文献搜索.
主要成果:
- LIQ表现出抗氧化,抗炎和抗增殖作用.
- 抗癌作用包括诱导细胞灭亡,抑制细胞增殖,调节信号通路 (NF-κB,PI3K/Akt/mTOR,MAPK).
结论:
- LIQ是癌症治疗的有前途的天然剂,在向瘤生长和存活方面发挥了多功能作用.
- 本次审查将传统医学与现代药理学联系起来,支持LIQ在癌症治疗中临床应用的潜力.
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