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三级淋巴细胞结构和免疫微环境特征在早期EGFR-突变性肺腺癌的预后作用

Wei-Hsun Hsu^1,2, Chia-Chi Hsu^1,2, Min-Shu Hsieh³

¹Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

|July 29, 2025

概括

在早期EGFR突变肺腺癌中,高三级淋巴细胞结构 (TLS) 密度预测了更长的无病生存期. TLS密度可以作为预后生物标志物,表明瘤中免疫活性增强.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

三级淋巴体结构 (TLSs) 在癌症预后中至关重要.
它们在早期EGFR突变肺腺癌中的作用尚不清楚.
复发仍然是一个挑战,尽管早期肺癌的结果更好.

研究的目的:

调查TLS在早期EGFR突变肺腺癌的预后价值.
分析TLS的分子特征与患者的治疗结果相关.
为了确定TLS密度是否是一个独立的预后因素.

主要方法:

在使用多重免疫组织化学 (IHC) 的瘤样本中确定和量化了TLS.
分析了TLS密度,PD-L1瘤比例得分 (TPS) 和无病生存率 (DFS) 之间的关联.
基因表达特征分析将高TLS密度组与低TLS密度组之间的瘤微环境特征进行比较.

主要成果:

高TLS密度与较长的DFS (43个月与20.5个月) 有显著的相关性.
在TLS密度和PD-L1 TPS或EGFR突变亚型之间没有发现任何关联.
转录组分析显示,在TLS密度高的瘤中,免疫反应基因被调高,在TLS密度低的瘤中,瘤促进途径被调高.

结论:

TLS密度是早期EGFR突变肺腺癌中DFS的潜在预后生物标志物.
TLS密度独立于PD-L1 TPS和EGFR突变亚型.
由于增强的免疫激活,TLS代表了改善这些患者的治疗结果的潜在治疗标.

关键词:

发生EGFR突变的肺腺癌.没有疾病的生存率.三级淋巴体结构的第三级淋巴体结构瘤免疫的微环境

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