结肠衰老和结肠直肠癌:不可忽视的相互作用及其翻译含义
Qiyan Yin1, Fen Qin1, Fangliu Gan1
1Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases, School of Life Sciences, Yunnan University, Kunming 650504, China.
Biology
|July 29, 2025
概括
结肠衰老,而不仅仅是时间上的年龄,积极推动结肠直肠癌 (CRC) 的发展. 了解这些衰老过程为检测,预防和治疗CRC提供了新的途径,特别是在老年人中.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 衰老研究研究 衰老研究
背景情况:
- 结肠直肠癌 (CRC) 的发病率随着年龄的增长而上升,但时间学年龄不足以解释CRC的发展.
- 结肠衰老,即结肠组织的生物衰老,越来越被认为是慢性结肠癌的关键驱动因素.
- 衰老的标志,如炎症和微生物组变化,与衰老的结肠的前瘤环境有关.
研究的目的:
- 综合审查结肠衰老和CRC病变之间的相互作用.
- 为了检查结肠内的衰老特征如何创造出一种支持瘤的环境.
- 探索结肠衰老研究对CRC预防和治疗的翻译潜力.
主要方法:
- 文学综合和对基本衰老特征的审查.
- 分析老化结肠中的分子和细胞变化.
- 检查干细胞,上皮屏障,炎症和CRC中的微生物组的作用.
主要成果:
- 结肠干细胞功能受损和上皮屏障破坏有助于CRC.
- 在衰老的结肠中,慢性炎症 (炎症) 和肠道失调会促进瘤的发展.
- 在衰老的结肠中,细胞外矩阵重塑和表观遗传失调促进了亲瘤原生微环境.
结论:
- 结肠衰老是CRC发展的一个关键,可修改的因素.
- 对结肠衰老的洞察力可以导致用于早期检测和风险分层的新生物标志物.
- 针对衰老途径为个性化CRC预防和治疗提供了机会,改善了老龄人口的结果.
相关概念视频
01:19The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K