早期断奶对羔羊肠道健康和免疫功能的影响:短期和长期影响
Chong Li1, Yunfei Xu1, Jiale Jia1
1College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Animals : an open access journal from MDPI
|July 29, 2025
概括
早期断奶会导致暂时的压力,但会导致绵羊的持续性肠道问题. 免疫和代谢途径的分子变化,涉及APOA4和NOS2等基因,驱动这种持续的肠道功能障碍.
科学领域:
- 动物科学动物科学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 断奶对动物健康有影响,但对肠道和免疫功能造成压力的分子机制尚不清楚.
- 早期断奶对心理和营养压力的差异性影响需要研究.
研究的目的:
- 调查早期断奶对羔羊压力生理学,免疫力和肠道健康的短期和长期影响.
- 为了确定调解这些效应的分子途径.
主要方法:
- 胡羊羔被分配给控制或早期断奶的群体.
- 血标志物,肠道形态,抗氧化能力,细胞亡和转录组形状在断奶后5天和28天被分析.
主要成果:
- 早期断奶会导致暂时的压力 (HPA轴,TNF-α),但持续的肠道重塑 (维卢斯高度,密室深度,氧化损伤).
- 转录学揭示了免疫功能,脂肪消化和新陈代谢基因 (例如,APOA4,NOS2,COX1) 的显著变化.
- NOS2作为一个将氧化应激与免疫细胞招募联系起来的枢纽基因而出现.
结论:
- 早期断奶带来最小的持久心理压力,但通过分子通路导致持续的肠道功能障碍.
- 像APOA4,NOS2和COX1这样的关键基因可能调节断奶引起的肠道功能障碍和代谢/免疫变化.
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