关于吸烟非洲裔美国人肺癌风险的祖先特定假设遗传反:戒烟的认知,情感和动机影响
Joel Erblich1, Khin Htet1, Camille Ragin2
1Department of Psychology, Hunter College, City University of New York, New York, NY 10065, USA.
Behavioral sciences (Basel, Switzerland)
|July 29, 2025
概括
向非洲裔美国吸烟者传达遗传风险和祖先信息显著影响他们感知到的肺癌风险和戒烟的动机. 这种个性化的遗传风险反对于行为改变干预至关重要.
科学领域:
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
- 行为科学 行为科学
背景情况:
- 遗传因素显著影响肺癌风险,特别是在非洲裔美国人 (AA) 吸烟者中.
- 在AA吸烟者中,祖先信息性遗传标记显示了肺癌风险的预测价值.
- 传递遗传风险信息对健康行为的影响尚未完全理解.
研究的目的:
- 评估传播遗传风险和祖先特定信息对非洲裔美国吸烟者的肺癌风险感知和戒烟动机的影响.
- 探索认知和情绪因素在对遗传风险反的反应中扮演的调解角色.
主要方法:
- 一项实验设计使用了166名非裔美国吸烟者,随机分配他们接受假设的遗传测试结果,表明低与高遗传风险以及欧洲与非洲祖先.
- 评估了参与者的认知 (感知风险),情绪 (担忧,痛苦) 和动机 (戒烟意图) 因素.
主要成果:
- 高遗传风险反显著增加了人们对肺癌风险的感知,对癌症的担忧,心理困扰和戒烟的动机.
- 非洲祖先的反显著增加了人们对肺癌的感知风险.
- 认知和情绪因素调解了遗传风险和祖先反对戒烟动机的影响.
结论:
- 将祖先特定的遗传风险信息纳入遗传咨询可以积极影响行为改变的认知,情感和动机因素.
- 个性化遗传风险沟通,特别是服务不足的人群,对于改善肺癌预防的健康结果至关重要.
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