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长期等离子体存储对无细胞DNA表观遗传生物标志物研究的影响

Jianming Shao1, Thao Nguyen1, Zejuan Li1,2,3

  • 1Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.

Biomolecules
|July 29, 2025
PubMed
概括

长期储存血显著影响无细胞DNA (cfDNA) 分析,增加基因组DNA (gDNA) 污染. 这种污染损害了cfDNA和5-hydroxymethylcytosine (5hmC) 测序质量,影响了生物标志物的可靠性.

关键词:
5 - 基甲基细胞氨酸5 - 基甲基细胞氨酸癌症 癌症 癌症 癌症 癌症没有细胞的DNA DNA.基因组 DNA DNA 的基因组.储存等离子体储存储存等离子体

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