在自闭症谱系障碍中的人类血液衍生 lncRNAs
Carmela Serpe1, Paola De Sanctis1, Marina Marini1
1Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Biomolecules
|July 29, 2025
概括
血液中的长非编码RNAs (lncRNAs) 显示出作为自闭症谱系障碍 (ASD) 生物标志物的希望. 需要进一步的研究来验证这些潜在的标志物用于早期ASD诊断和向治疗.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 生物标志物发现发现
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育障碍,在临床上被诊断为3岁左右.
- 早期诊断和治疗目标的识别对于管理ASD至关重要.
- 长非编码RNAs (lncRNAs) 正在成为各种疾病的潜在生物标志物,包括神经疾病.
研究的目的:
- 对人类血液衍生 lncRNAs作为ASD潜在生物标志物的原始研究进行审查.
- 根据其与ASD相关的生物过程或高通量发现的关联来对已识别的lncRNA进行分类.
- 概述未来的研究重点,以验证lncRNAs作为可靠的ASD生物标志物.
主要方法:
- 对原始研究进行系统审查,调查ASD中的血液衍生 lncRNAs.
- 基于它们参与ASD相关途径或高通量查的lncRNAs的分类.
- 分析当前的研究状况,并确定未来的研究需求.
主要成果:
- 在ASD患者中,已经确定了几种失调的血液衍生lncRNAs.
- lncRNAs根据其与ASD病理生理学或通过大规模分析发现的功能相关性进行分组.
- 针对ASD生物标志物的lncRNA研究领域仍处于芽阶段.
结论:
- 血液衍生的 lncRNAs 是ASD生物标志物开发的一个有希望的领域.
- 未来的研究应该专注于在更大,更年轻的队列中验证lncRNAs,并将ASD与其他神经系统疾病区分开来.
- 整合多样化的数据源对于建立可靠的 lncRNA生物标志物网络进行临床应用至关重要.
相关概念视频
lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
Autism Spectrum Disorder
338
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
338
Non-LTR Retrotransposons
11.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.9K
Genome-wide Association Studies-GWAS
14.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.2K
Alternative RNA Splicing
21.7K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.7K


