在炎症性肠病中短链脂肪酸的定量变化:系统性审查和元分析
Laura Chulenbayeva1,2, Zharkyn Jarmukhanov1, Karlygash Kaliyekova3
1Laboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Biomolecules
|July 29, 2025
概括
像丁酸盐这样的短链脂肪酸 (SCFA) 在炎症性肠病 (IBD) 中显著减少. 这一元分析证实IBD患者的SCFA水平较低,特别是在活跃疾病期间,突出了潜在的治疗点.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 减少短链脂肪酸 (SCFA) 的水平与肠道屏障功能受损和炎症性肠病 (IBD) 中的免疫失调有关.
- 脂肪酸在维持肠道健康方面发挥着至关重要的作用,而它们的枯竭与炎症增加有关.
- 针对微生物组的疗法显示出IBD治疗的希望,这是由于SCFA的作用.
研究的目的:
- 系统地分析IBD患者SCFA水平的变化.
- 调查SCFA水平与IBD的发生和进展之间的关联.
- 评估饮食干预对IBD中SCFA水平的影响.
主要方法:
- 从2014年到2024年7月进行了全面的文献搜索.
- 使用随机效应模型计算标准化平均差异 (SMD) 和95%置信区间.
- 进行了子组分析,以比较不同IBD类型和疾病活性中的SCFA水平.
主要成果:
- 与健康对照组相比,便中的SCFA含量,包括酸盐,酸盐和酸盐,在所有IBD亚组中都明显较低.
- 活性IBD显示出更明显的丁酸盐减少 (p=0.004),而性结肠炎 (UC) 显示出酸盐显著减少 (p=0.03).
- 在IBD患者的饮食干预导致SCFA水平增加,特别是丁酸盐 (SMD=1.03),表明治疗潜力.
结论:
- 这一元分析证实IBD患者便SCFA水平显著降低.
- 在活跃的疾病阶段,SCFA的枯竭特别明显,在克罗恩病 (CD) 中最为明显.
- 饮食调节是恢复SCFA水平和管理IBD的有希望的治疗策略.
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