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细菌特征和抗生素耐药性模式在胆汁期望从急性胆管炎患者:一个多中心国际研究

Matei-Alexandru Cozma^1,2, Mihnea-Alexandru Găman^3,4, Camelia Cristina Diaconu^1,5

¹Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Antibiotics (Basel, Switzerland)

|July 29, 2025

概括

在急性胆道炎 (AC) 患者中,抗生素耐药性 (AR) 和多药耐药性 (MDR) 细菌的发生率在罗马尼亚和法国之间显著不同. 胆汁培养对于指导治疗和减少AC中的AR至关重要.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
临床药房临床药房

背景情况:

抗生素耐药性 (AR) 和多药耐药性 (MDR) 细菌对全球健康构成重大挑战.
在不同地理区域的急性胆道炎 (AC) 患者中观察到AR率和细菌发病率的变化.

研究的目的:

描述和比较来自两个欧洲三级医疗中心的AC患者的微生物谱和AR模式.
为了确定罗马尼亚和法国之间的细菌病原体及其耐药性概况的差异.

主要方法:

从2022年4月到2023年10月进行了一项前性,观察性,多中心研究.
包括从科伦蒂娜临床医院 (罗马尼亚布加勒斯特) 和Haut-Lévêque医院 (法国波尔多) 诊断出AC和阳性胆汁培养的患者.

主要成果:

大肠杆菌 (Escherichia coli) 和伪杆菌 (Pseudomonas) 种类. 在罗马尼亚占主导地位,而Enterococcus faecalis和E. 大肠杆菌在法国最常见.
与法国 (7.21%) 相比,罗马尼亚 (21.16%) 的MDR菌株更为普遍.
罗马尼亚观察到对,梅罗,皮佩拉西林/塔扎巴克坦和勒沃素的耐药性更高.

结论:

在AC患者中存在严重的AR率和MDR细菌患病率的地理差异.
胆汁培养对于定制抗生素治疗是有效和经济的,有可能降低AR和并发症.

关键词:

急性胆管炎是什么情况抗微生物耐药性抗微生物耐药性胆培养是一种胆培养.多重耐药细菌是多种耐药性的细菌.

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