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Updated: Sep 13, 2025

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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
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全国范围的空间模式以及与巴西的面孔裂相关的孕产妇和出生相关因素
Luis Gustavo Souza Santos1, Vandilson Rodrigues1,2, Jessilene Ribeiro Rocha1
1Dentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.
概括
巴西的Orofacial裂发病率显示空间聚类,特别是在南部和东南部. 关键因素包括母亲的年龄,教育,早产,低出生体重和新生儿的种族/种族.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 空间分析 空间分析
背景情况:
- 面腔裂是复杂病因的常见出生缺陷.
- 了解空间模式和相关因素对于有针对性的干预至关重要.
研究的目的:
- 为了确定巴西 orofacial 裂的空间聚类.
- 调查与裂发病率相关的孕产妇和分娩相关因素.
主要方法:
- 全国范围内的生态研究使用巴西活产信息系统 (SINASC) 数据 (2001-2022).
- 作为空间单位的市镇;对母亲的年龄,教育,新生儿的性别,妊娠年龄,出生体重和皮肤颜色/种族的分析.
- 全球和本地莫兰斯I指数用于空间自相对应分析.
主要成果:
- 发现了明显的口面裂的空间聚类 (莫兰的I=0.121).
- 在南/东南地区观察到高发病率集群 (高-高);在东北地区观察到低发病率集群 (低-低).
- 高高的集群与较年轻/较年长的母亲年龄,较低的母亲教育,较高的早产/低出生体重率,以及较高比例的白人新生儿有关.
结论:
- 巴西的面部裂发病率表现出显著的空间模式.
- 母亲的社会人口统计特征,围产期的结果,以及新生儿的种族/种族与 orofacial 裂的空间聚类有关.
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