豆粉衍生发酵液通过5-HT调节和肠道微生物群调节缓解便秘:一个实体研究
Tao Ma1, Mengtian Zhou2, Xinru Zhang2
1College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
用植物乳杆菌 (MBSFL) 发酵的豆粉有效治疗小鼠的便秘. 这种干预可以使肠道功能和微生物平衡正常化,改善胃肠道运动性和缓解症状.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 便秘是一种普遍的胃肠道疾病,严重影响患者的生活质量.
- 为便秘制定有效的治疗策略仍然是一个关键的临床需求.
研究的目的:
- 研究发酵豆粉 (MBSFL) 在缓解便秘方面的功效.
- 在诱导便秘的小鼠模型中阐明MBSFL的潜在机制.
主要方法:
- 在使用科特里莫克萨的雄性ICR小鼠中诱导便秘.
- 通过发酵豆粉和乳酸菌植物菌制备的MBSFL是口服的.
- 分析的关键参数包括便特征,胃肠道过境,血清生物标志物 (NO,VIP,SP,5-HT) 和肠道基因表达 (5HTR4,SERT,MAOA).
主要成果:
- MBSFL治疗显著改善了便中的水含量,并减少了第一个便的延迟时间.
- 它增强了胃排空和小肠推进,同时调节了NO,VIP,SP和5-HT的血清水平.
- MBSFL改变了肠道基因表达 (上调5HTR4和SERT,下调MAOA),并有利地改变了肠道微生物群的组成,增加了Lactobacillus和Dubosiella,同时减少了Mucispirillum.
结论:
- 发酵豆粉 (MBSFL) 显示出对便秘的显著治疗潜力.
- MBSFL通过调节5-HT通路并恢复肠道微生物群平衡来缓解便秘.
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