中心对比度灵敏度作为一种结局衡量标准,在格拉库马的随机对照试验中 - - 一个系统性审查
Alexander Sverstad1, Jens Riis Møller2, Gianni Virgili3,4
1Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0450 Oslo, Norway.
Life (Basel, Switzerland)
|July 29, 2025
概括
中央对比度敏感性 (CCS) 是一种潜在的青光眼早期标志物. 这次审查发现,在青光眼试验中测量CCS的方法各不相同,标准化有限,近期兴趣下降.
科学领域:
- 眼科医生 眼科 眼科
- 视觉神经科学是一种神经科学.
- 临床试验 临床试验
背景情况:
- 标准自动周边测量 (SAP) 是青光眼的黄金标准,评估外周视力.
- 中央对比度敏感性 (CCS) 显示出希望,作为眼损伤的早期功能指标.
- 系统性审查,以巩固用于对格洛科马随机对照试验 (RCT) 中的CCS测量方法.
研究的目的:
- 系统地审查和描述用于测量中心对比度灵敏度 (CCS) 的各种方法,在涉及青光眼患者的随机对照试验 (RCT) 中.
- 为了确定在青光眼研究中使用的CCS测试的流行率和类型.
- 评估格洛科马RCT中CCS测量的标准化和趋势.
主要方法:
- 综合数据库搜索 (MEDLINE,Embase,CINAHL,Cochrane,Epistemonikos,ClinicalTrials.gov) 更新至 2025 年 2 月.
- 纳入标准:RCT报告了青光眼,疑似青光眼或眼睛高血压中的CCS结果.
- 使用描述性统计数据;由于审查的性质,没有偏差评估风险.
主要成果:
- 31项研究符合1066个记录的资格标准;样本大小小 (中位数23) 很小.
- 确定了11种不同的CCS测量方法;五项研究遗漏了方法细节.
- CSV-1000是最常见的CCS测试 (11项研究);干预主要是局部药物 (例如,蒂莫洛尔).
结论:
- 在眼RCT中存在各种CCS测量技术,缺乏标准化.
- 小规模的研究,可变的报告和较旧的研究日期表明,对CCS的关注程度正在减少,因为它是青光眼RCT的结果.
- 可能需要进一步的研究,以建立标准化的CCS测量标准,用于玻璃眼临床试验.
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