灰马黑色素瘤-穿着羊皮的狼
Daniela M Brodesser1, Karin Schlangen2, Alexandro Rodríguez-Rojas3
1Research Group Oncology (RGO), Centre for Equine Health and Research, Department for Small Animals and Horses, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
International journal of molecular sciences
|July 29, 2025
概括
灰色马很容易患上恶性黑色素瘤 (MM). 这项研究揭示了与人类癌症相似的灰马黑色素瘤 (ghM) 的分子途径,这表明这种马类疾病的潜在治疗点.
科学领域:
- 兽医瘤学 兽医瘤学
- 比较病理学比较病理学
- 分子生物学分子生物学
背景情况:
- 恶性黑色素瘤 (MM) 影响人类和动物,灰色马具有较高的易感性.
- 虽然multiomics已经推进了人类MM研究,但马类黑色素瘤的病变和独特的休眠状态仍然不太了解.
- 了解灰马黑色素瘤 (ghM) 可以为比较瘤学和黑色素瘤生物学提供见解.
研究的目的:
- 为了研究灰马恶性黑色素瘤的分子病变.
- 将ghM的分子路径与人体黑色素瘤和其他癌症的分子路径进行比较.
- 为了确定ghM治疗的潜在分子点.
主要方法:
- 在灰色马的黑色素瘤组织和完整皮肤上使用RNA测序 (RNAseq) 的转录组分析.
- 来自灰色马的原发性瘤细胞和正常皮肤纤维细胞的建立,用于蛋白质表达概况.
- 生物信息分析以确定过度代表的分子途径和关键信号分子.
主要成果:
- 灰马黑色素瘤 (ghM) 呈现出类似于人类黑色素瘤和癌症的分子通路过度代表,包括RAS/RAF/MAPK,IRS/IGF1R和PI3K/AKT信号.
- 像RAC1,RAS和BRAF这样的关键分子可能在ghM中存在激活突变,类似于人类黑色素瘤.
- 在ghM中,PTEN中潜在的功能丧失突变也被建议.
结论:
- 灰马黑色素瘤 (ghM) 被证实是一种恶性瘤,与人类癌症有分子相似之处.
- 已识别的信号通路和潜在的突变为进一步研究ghM病原体提供了途径.
- 专注于ghM突变状态的未来研究将提高对这种普遍存在的马病的理解,并可能指导治疗策略.
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